|
Symbol Name ID |
Clcnkb
chloride channel, voltage-sensitive Kb MGI:1930643 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | Hyperchloriduria |
Renal magnesium wasting |
Increased urinary potassium |
Renal potassium wasting |
Hypernatriuria |
Hypocalciuria |
Renal salt wasting |
Enuresis |
Nocturia |
Nephrocalcinosis |
Decreased glomerular filtration rate |
Polyuria |
Renal insufficiency |
Impaired renal tubular reabsorption of chloride |
| Disease(s) Associated with CLCNKA | ||||||||||||||
| Bartter disease type 4b | ||||||||||||||
| Disease(s) Associated with CLCNKB | ||||||||||||||
| Bartter disease type 3 | ||||||||||||||
| Bartter disease type 4b | ||||||||||||||
| Gitelman syndrome | ||||||||||||||
| Mouse Phenotypes | renal/urinary system phenotype |
abnormal kidney afferent arteriole morphology |
abnormal kidney efferent arteriole morphology |
abnormal kidney vasculature morphology |
enlarged kidney |
enlarged urinary bladder |
increased urine chloride ion level |
increased urine potassium level |
increased urine sodium level |
abnormal urine homeostasis |
increased urine magnesium level |
decreased urine osmolality |
increased urine prostaglandin level |
abnormal kidney morphology |
abnormal juxtaglomerular apparatus morphology |
juxtaglomerular cell hyperplasia |
hydronephrosis |
small kidney |
abnormal distal convoluted tubule morphology |
dilated distal convoluted tubule |
abnormal loop of Henle ascending limb thick segment morphology |
abnormal urinary bladder morphology |
decreased renal glomerular filtration rate |
abnormal renal transport |
abnormal renal sodium ion transport |
polyuria |
|
| Availability | Mouse Genotype | ||||||||||||||||||||||||||
| Clcnkatm1Suc/Clcnkatm1Suc | |||||||||||||||||||||||||||
| Clcnkbem1(IMPC)Mbp/Clcnkbem1(IMPC)Mbp | |||||||||||||||||||||||||||
| Clcnkbem1Haca/Clcnkbem1Haca | |||||||||||||||||||||||||||
| Clcnkbtm1.1Doel/Clcnkbtm1.1Doel | * | ||||||||||||||||||||||||||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
|
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 04/23/2024 MGI 6.23 |
|
|
|
||
Analysis Tools